A bit of background on this 1995 song from Richard D. James from Wikipedia:

The piece is named after a trade name for the drug Salbutamol, which is prescribed for the treatment of asthma. A reported side effect of this drug is tinnitus (Citation needed), a high pitched ringing in the ears. James utilized this effect in “Ventolin”, incorporating a piercing high-pitched ringing sound throughout the track. The music also incorporates heavily distorted techno beats. The resulting effect has been cited as “one of the most abrasive singles ever recorded”.